MovDisordV3, Main, Exploration, bibRecord, 001824

Abnormal cortical and brain stem plasticity in Gilles de la Tourette syndrome

Identifieur interne : 001824 ( Main/Exploration ); précédent : 001823; suivant : 001825

Abnormal cortical and brain stem plasticity in Gilles de la Tourette syndrome

Auteurs : Antonio Suppa [Italie] ; Daniele Belvisi [Italie] ; Matteo Bologna [Italie] ; Luca Marsili [Italie] ; Isabella Berardelli [Italie] ; Germana Moretti [Italie] ; Massimo Pasquini [Italie] ; Giovanni Fabbrini [Italie] ; Alfredo Berardelli [Italie]

Source :

Movement Disorders [ 0885-3185 ] ; 2011-08-01.

RBID : ISTEX:1DFB013943F6E3404E0AE55A423AAB0C27AC7244

Descripteurs français

Pascal (Inist)
- Cortex moteur, Pathologie du système nerveux, Plasticité, Syndrome de Gilles de la Tourette, Tronc cérébral.

English descriptors

KwdEn :
- Adolescent, Adult, Analysis of Variance, Biophysics, Brain Stem (physiopathology), Brain stem, Cerebral Cortex (physiopathology), Electric Stimulation (methods), Evoked Potentials, Motor (physiology), Female, Gilles de la Tourette syndrome, Humans, Long-Term Potentiation (physiology), Long-Term Synaptic Depression (physiology), Male, Middle Aged, Motor cortex, Nervous system diseases, Neuronal Plasticity (physiology), Plasticity, Statistics, Nonparametric, Tourette Syndrome (pathology), Young Adult, brain stem, plasticity, primary motor cortex.
MESH :
- methods : Electric Stimulation.
- pathology : Tourette Syndrome.
- physiology : Evoked Potentials, Motor, Long-Term Potentiation, Long-Term Synaptic Depression, Neuronal Plasticity.
- physiopathology : Brain Stem, Cerebral Cortex.
- Adolescent, Adult, Analysis of Variance, Biophysics, Female, Humans, Male, Middle Aged, Statistics, Nonparametric, Young Adult.

Abstract

We investigated primary motor cortex and brain stem plasticity in patients with Gilles de la Tourette syndrome. The study group comprised 12 patients with Gilles de la Tourette syndrome and 24 healthy subjects. Patients were clinically evaluated using the Yale Global Tic Severity Scale. We tested cortical plasticity by conditioning left primary motor cortex with intermittent or continuous theta‐burst stimulation in 2 separate sessions. Test stimulation consisted of 20 motor‐evoked potentials recorded from right first interosseous muscle before and after theta‐burst stimulation. We also tested brain stem plasticity by conditioning the right supraorbital nerve with facilitatory electric high‐frequency stimulation delivered at the same time as the late response of the blink reflex or inhibitory high‐frequency stimulation delivered before the late response on 2 separate sessions. Test stimulation consisted of 10 blink reflexes from the right orbicularis oculi muscle before and after high‐frequency stimulation. After intermittent theta‐burst stimulation, motor‐evoked potential amplitudes in healthy subjects increased significantly but remained unchanged in patients. Similarly, after continuous theta‐burst stimulation, motor‐evoked potential amplitudes decreased significantly in healthy subjects but did not in patients. After facilitatory high‐frequency stimulation, the blink reflex late response area in healthy subjects increased, whereas after inhibitory high‐frequency stimulation, it decreased. Conversely, in patients, both interventions left the blink reflex late response area unchanged. The lack of the expected inhibitory and facilitatory changes in motor‐evoked potential amplitudes and blink reflex late response area suggests that abnormal plasticity in the primary motor cortex and brain stem play a role in the pathophysiology of Gilles de la Tourette syndrome. © 2011 Movement Disorder Society

Url:

https://api.istex.fr/document/1DFB013943F6E3404E0AE55A423AAB0C27AC7244/fulltext/pdf

DOI: 10.1002/mds.23706

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Analysis of Variance</term>
<term>Biophysics</term>
<term>Brain Stem (physiopathology)</term>
<term>Brain stem</term>
<term>Cerebral Cortex (physiopathology)</term>
<term>Electric Stimulation (methods)</term>
<term>Evoked Potentials, Motor (physiology)</term>
<term>Female</term>
<term>Gilles de la Tourette syndrome</term>
<term>Humans</term>
<term>Long-Term Potentiation (physiology)</term>
<term>Long-Term Synaptic Depression (physiology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor cortex</term>
<term>Nervous system diseases</term>
<term>Neuronal Plasticity (physiology)</term>
<term>Plasticity</term>
<term>Statistics, Nonparametric</term>
<term>Tourette Syndrome (pathology)</term>
<term>Young Adult</term>
<term>brain stem</term>
<term>plasticity</term>
<term>primary motor cortex</term>
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<term>Long-Term Synaptic Depression</term>
<term>Neuronal Plasticity</term>
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<term>Cerebral Cortex</term>
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<term>Analysis of Variance</term>
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<term>Pathologie du   système nerveux</term>
<term>Plasticité</term>
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<front><div type="abstract" xml:lang="en">We investigated primary motor cortex and brain stem plasticity in patients with Gilles de la Tourette syndrome. The study group comprised 12 patients with Gilles de la Tourette syndrome and 24 healthy subjects. Patients were clinically evaluated using the Yale Global Tic Severity Scale. We tested cortical plasticity by conditioning left primary motor cortex with intermittent or continuous theta‐burst stimulation in 2 separate sessions. Test stimulation consisted of 20 motor‐evoked potentials recorded from right first interosseous muscle before and after theta‐burst stimulation. We also tested brain stem plasticity by conditioning the right supraorbital nerve with facilitatory electric high‐frequency stimulation delivered at the same time as the late response of the blink reflex or inhibitory high‐frequency stimulation delivered before the late response on 2 separate sessions. Test stimulation consisted of 10 blink reflexes from the right orbicularis oculi muscle before and after high‐frequency stimulation. After intermittent theta‐burst stimulation, motor‐evoked potential amplitudes in healthy subjects increased significantly but remained unchanged in patients. Similarly, after continuous theta‐burst stimulation, motor‐evoked potential amplitudes decreased significantly in healthy subjects but did not in patients. After facilitatory high‐frequency stimulation, the blink reflex late response area in healthy subjects increased, whereas after inhibitory high‐frequency stimulation, it decreased. Conversely, in patients, both interventions left the blink reflex late response area unchanged. The lack of the expected inhibitory and facilitatory changes in motor‐evoked potential amplitudes and blink reflex late response area suggests that abnormal plasticity in the primary motor cortex and brain stem play a role in the pathophysiology of Gilles de la Tourette syndrome. © 2011 Movement Disorder Society</div>
</front>
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<name sortKey="Belvisi, Daniele" sort="Belvisi, Daniele" uniqKey="Belvisi D" first="Daniele" last="Belvisi">Daniele Belvisi</name>
<name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name>
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<name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name>
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<name sortKey="Moretti, Germana" sort="Moretti, Germana" uniqKey="Moretti G" first="Germana" last="Moretti">Germana Moretti</name>
<name sortKey="Pasquini, Massimo" sort="Pasquini, Massimo" uniqKey="Pasquini M" first="Massimo" last="Pasquini">Massimo Pasquini</name>
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Movement Disorders (revue)

Abnormal cortical and brain stem plasticity in Gilles de la Tourette syndrome

Abnormal cortical and brain stem plasticity in Gilles de la Tourette syndrome

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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